Title  要求简练，精确  _ Compassionate use of bevacizumab (Avastin) in children and young adults with refractory or recurrent solid tumors.  _ Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.  _ Proteomics Approaches to the Systems Biology of Cardiovascular Diseases _ Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis.  _ Lack of early bevacizumab-related skeletal radiographic changes in children with neuroblastoma.  _ Interleukin-4 activates androgen receptor through CBP/p300  _ Trisomy 8 in an allogeneic stem cell transplant recipient representative of a donor-derived constitutional abnormality.  _ Disruption of diacylglycerol metabolism impairs the induction of T cell anergy _ T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase- _ High-dose conformal RT improves tumor control in patients with prostate cancer _ Vitamin D concentration does not affect the risk of prostate cancer  _ Liver resection with salvage transplantation for hepatocellular carcinoma  _ The impact of histopathologic diagnosis on the proper management of testis neoplasms _ Prostate stem cell antigen is associated with diffuse-type gastric cancer _ Multiple myeloma: high-risk immunophenotypes identified  _ Increased c-kit expression predicts poor outcome in acute myeloid leukemia _ Global Analysis of the Meiotic Crossover Landscape  _ Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integrity _ Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis  _ Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to Neurodegeneration  _ Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease:  Results of the randomized, double-blind, placebo-controlled INEF study.  _ Global experiences with vardenafil in men with erectile dysfunction and underlying conditions.     _ Noninvasive cardiac imaging: implications for risk assessment in adolescents and young 

adults.  _ Transforming growth factor beta1 T29C gene polymorphism and hypertension: Relationship with cardiovascular and renal damage.  _ A comparison of hormone therapies on the urinary excretion of prostacyclin and thromboxane A2.  _ Repair of an infected aortic aneurysm using an aortic allograft and a venous autograft: Report of a case.  _ Circulating Leptin and Stress-induced Cardiovascular Activity in Humans.  _ Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study.  _ Long-term cardiovascular outcomes following ischemic heart disease in patients with and  without peripheral vascular disease.  _ Reduced renal function and sleep-disordered breathing in community-dwelling elderly men.  _ Intracoronary pharmacotherapy in the management of coronary microvascular dysfunction.  _ Inhibition of platelet aggregation by combined therapy with aspirin and cilostazol after off-pump coronary artery bypass surgery.  _ Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice Abstract 要求简洁，连贯  _ The acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. We report that untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and KrasD12, or polyoma middle T, and introduced into the systemic circulation of a mouse can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the  bloodstream and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors.  _ Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis  (CF), we still lack answers to many questions about the pathogenesis of the disease, and it remains incurable. Mice with a disrupted CFTR gene have greatly facilitated CF studies, but the mutant mice do not develop the characteristic manifestations of human CF,  including abnormalities of the pancreas, lung, intestine, liver, and other organs. Because pigs share many anatomical and physiological features with humans, we generated pigs with a targeted disruption of both CFTR alleles. Newborn pigs lacking CFTR exhibited defective chloride transport and developed meconium ileus, exocrine pancreatic  destruction, and focal biliary cirrhosis, replicating abnormalities seen in newborn humans

with CF. The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment. _ Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in recognition of antigens in the adaptive immune system of jawless vertebrates. Combinatorial assembly of leucine-rich repeat (LRR) gene segments achieves the  required repertoire for antigen recognition. We have determined a crystal structure for a VLR-antigen complex, VLR RBC36 in complex with the H-antigen trisaccharide from human blood type O erythrocytes, at 1.67 angstrom resolution. RBC36 binds the H-trisaccharide on the concave surface of the LRR modules of the solenoid structure where three key hydrophilic residues, multiple van der Waals interactions, and the highly variable insert of the carboxyl-terminal LRR module determine antigen recognition and specificity. The concave surface assembled from the most highly variable regions of the LRRs, along with diversity in the sequence and length of the highly variable insert, can account for the recognition of diverse antigens by VLRs.  _ A 51-year-old man with a diagnosis of myelodysplasia and non-Hodgkin's lymphoma underwent an unmatched allogenic bone marrow transplantation and was treated posttransplant with chronic immunosuppressive medication. Eight months following transplantation, he presented with progressive dysarthria, cognitive and visual decline. Evaluation included brain magnetic resonance (MR) imaging demonstrating multifocal areas of increased T2 and FLAIR (fluid attenuated inversion recovery) signals involving the left frontal, parietal, and occipital lobes. The MR lesions demonstrated diffuse  increased signal on DWI (diffusion-weighted images) and normal to low signal on ADC (apparent diffusion coefficients). Contrast-enhanced T1 images were unremarkable. Lumbar puncture revealed a mild elevation in cerebrospinal fluid (CSF) protein. CSF PCR assay for viral DNA fragments were negative on two occasions. Serum serology for HIV was negative as well. A brain biopsy was subsequently performed. The clinical and neuroimaging differential diagnoses as well as neuropathologic correlation are presented. _ In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability to undergo differentiation toward cells of different lineages. _ These results suggested that  _ However, there are still obstacles in  _ The major challenge for successful drug development is identifying delivery strategies that can be translated to the clinic.  _ This review will discuss progress in developing and testing small RNAi-based drugs and  potential obstacles.  _ This review highlights what  _ In addition, there are indications that  _ Proper consideration of all of these issues will be necessary in _ These studies provide